Distribution of an inducible hexose-phosphate transport system among various bacteria.
نویسنده
چکیده
A transport system for glucose-6-phosphate, which is inducible by glucose-6-phosphate but not glucose or beta-glycerophosphate, occurs in a variety of bacterial genera. The correlation of the fosfomycin sensitivity with the presence of the transport system is described.
منابع مشابه
Role of the phosphotransferase system in Escherichia coli strains deficient in hexose phosphate transport.
In Escherichia coli, glucose 6-phosphate is transported via the Uhp system which is inducible by glucose 6-phosphate. We showed that, in a uhp-deficient strain, glucose 6-phosphate was dephosphorylated in the periplasm and that the resulting glucose was subsequently transported into the cells via the phosphotransferase system. The uptake of glucose generated from glucose 6-phosphate allowed the...
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Hexose phosphate is an important carbon source within the cytoplasm of host cells. Bacterial pathogens that invade, survive, and multiply within various host epithelial cells exploit hexose phosphates from the host cytoplasm through the hexose phosphate transport (HPT) system to gain energy and synthesize cellular components. In Escherichia coli, the HPT system consists of a two-component regul...
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The induction of the hexose-6-phosphate transport system was investigated. Glucose-6-phosphate (G6P) at concentrations as low as 10(-4)m was able to induce this system in wild-type cells, as well as in mutants lacking phosphoglucose isomerase or G6P dehydrogenase. Growth in the presence of fructose-6-phosphate (F6P) induced the system only if the cells contained phosphoglucose isomerase. Furthe...
متن کاملIsolation and characterization of mutations affecting the transport of hexose phosphates in Escherichia coli.
Mutants of Escherichia coli defective in the hexose phosphate transport system were isolated. Negative selection by penicillin treatment or positive selection with phosphonomycin was employed. These mutants grew normally on all carbon sources other than hexose phosphates. The map location of the mutations in 18 independently isolated mutant strains was investigated by transduction crosses. All ...
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ورودعنوان ژورنال:
- Journal of bacteriology
دوره 116 2 شماره
صفحات -
تاریخ انتشار 1973